Disable office click to run

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When Outlook is pinned to the desktop Taskbar, hold Ctrl+Shift and right click on the Taskbar icon.

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You only need run as administrator one time, and once you make the change it will be in effect for all Outlook profiles on the computer. Note: To change the Programmatic Access setting in Outlook's Trust Center, you need to run Outlook as an Administrator. Programmatic Access settings can also be controlled through Group Policy. Non-administrator users can see the current setting but will not be able to change it. These settings are only enabled if the current user is an administrator on the computer. I want to be able to turn this off and on so I can avoid this message. I have to click on the allow/deny for each email. I have an application that sends email out.

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They are greyed out and I cannot change them. How can I change the programmatic access options.